Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality: An Individual-Level Pooled Analysis of 30 Cohort Studies
Cardiovascular Disease (CVD)
Year Published: 2019
Journal
Circulation
Authors
Matti Marklund , Jason H.Y. Wu , Fumiaki Imamura , Liana C. Del Gobbo , Amanda Fretts , Janette de Goede , Peilin Shi , Nathan Tintle , Maria Wennberg , Stella Aslibekyan , Tzu-An Chen , Marcia C. de Oliveira Otto , Yoichiro Hirakawa , Helle Højmark Eriksen , Janine Kröger , Federica Laguzzi , Maria Lankinen , Rachel A. Murphy , Kiesha Prem , Cécilia Samieri , Jyrki Virtanen , Alexis C. Wood , Kerry Wong , Wei-Sin Yang , Xia Zhou , Ana Baylin , Jolanda M.A. Boer , Ingeborg A. Brouwer , Hannia Campos , Paulo H. M. Chaves , Kuo-Liong Chien , Ulf de Faire , Luc Djoussé , Gudny Eiriksdottir , Naglaa El-Abbadi , Nita G. Forouhi , J Michael Gaziano , Johanna M. Geleijnse , Bruna Gigante , Graham Giles , Eliseo Guallar , Vilmundur Gudnason , Tamara Harris , William S. Harris , Catherine Helmer , Mai-Lis Hellénius , Allison Hodge , Frank B. Hu , Paul F. Jacques , Jan-Håkan Jansson , Anya Kalsbeek , Kay-Tee Khaw , Woon-Puay Koh , Markku Laakso , Karin Leander , Hung-Ju Lin , Lars Lind , Robert Luben , Juhua Luo , Barbara McKnight , Jaakko Mursu , Toshiharu Ninomiya , Kim Overvad , Bruce M. Psaty , Eric Rimm , Matthias B. Schulze , David Siscovick , Michael Skjelbo Nielsen , Albert V. Smith , Brian T. Steffen , Lyn Steffen , Qi Sun , Johan Sundström , Michael Y. Tsai , Hugh Tunstall-Pedoe , Matti I. J. Uusitupa , Rob M. van Dam , Jenna Veenstra , W.M. Monique Verschuren , Nicholas Wareham , Walter Willett , Mark Woodward , Jian-Min Yuan , Renata Micha , Rozenn N. Lemaitre , Dariush Mozaffarian , and Ulf Risérus
Methods
In this review, authors analyzed 30 studies across 13 countries in 68,659 participants. The objective was to examine the effects of linoleic acid (a polyunsaturated fat in peanuts) on risk of cardiovascular disease.
Key Findings
Key Findings: Higher levels of linoleic acid were associated with a 7% lower incidence of cardiovascular disease, 22% lower incidence of CVD mortality, and 12% reduced incidence of stroke. Authors conclude: “These results support a favorable role for linoleic acid in CVD prevention."