Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen
Allergy
Year Published: 2015
Journal
PNAS
Authors
Peter E. Deak, Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M. Kloepfer, Matthew J. Turner, Neal Smith, Wayne G. Shreffler, Tanyel Kiziltepe, Mark H. Kaplan, and Basar Bilgicer
Methods
In this study, authors tested the ability of an inhibitor to block the IgE receptor that triggers an allergic reaction to peanuts.
Key Findings
Key Findings: "Those molecules, which they named covalent heterobivalent inhibitors, were found to stop allergic reactions by stopping IgES from latching on to peanut proteins."
