Effect of antioxidant protection by p-coumaric acid on low-density lipoprotein cholesterol oxidation

Year Published: 2000


Am J Physiol Cell Physiol


Zang LY1, Cosma G, Gardner H, Shi X, Castranova V, Vallyathan V


This study examined the effects of p-coumaric acid administration on LDL cholesterol and LDL oxidation in rats. The study was designed to look at the mechanisms by which p-coumaric acid acts as an antioxidant. P-coumaric acid is a polyphenol found in peanuts.

Key Findings

Key Findings: Oral administration of p-coumaric acid for 30 days significantly inhibited LDL oxidation and also lowered LDL cholesterol.