Year Published: 2019
Expert Rev Clin Immunol
Langlois A, Graham F, Bégin P
This review discussed the proposed mechanism of action of epicutaneous immunotherapy (EPIT) in both rodents and humans. EPIT is a method that delivers peanut allergen through the skin in order to induce tolerance to the allergen. Authors also looked at efficacy and safety data from clinical trials with peanut EPIT, and discussed its potential role in the future management of peanut allergy.
Like oral immunotherapy (OIT), EPIT seems to promote immunological tolerance over time. However, more studies are needed in this area to better understand the mechanisms behind EPIT.