Hydroalcoholic extract of leaf of Arachis hypogaea L. (Fabaceae) did not induce toxic effects in the repeated-dose toxicity study in rats

Year Published: 2020


Regul Toxicol Pharmacol


Cossetin JF, de Almeida AS, de David Antoniazzi CT, Kudsi SQ, Engelmann AM, Guex CG, de Oliveira JS, Theisen MC, Ritter CS, Doleski PH, da Silva Brum E, Dalenogare DP, Peres DS, Pintos FG, de Andrade CM, Leal DBR, Oliveira SM, de Freitas Bauermann L, Riéffel RC, Sagrillo MR, Machado AK, Santos ARS, Trevisan G


Peanut leaves are commonly used to relieve insomnia in Asia. The aim of this study was to test the toxicity of peanut leaves in high doses. High doses of peanut leaf extract were given to rats over 28 days and the effects were monitored.

Key Findings

Key Findings: The peanut leaf extract did not induce toxicity. Earlier studies showed that it has antioxidant and anti-inflammatory effects.