l-Arginine and COVID-19: An Update

Year Published: 2022




Ayobami Adebayo 1,Fahimeh Varzideh 1,2,Scott Wilson 1,Jessica Gambardella 1,2,Michael Eacobacci 1,Stanislovas S. Jankauskas 1,2ORCID,Kwame Donkor 1,Urna Kansakar 1,2,Valentina Trimarco 3,Pasquale Mone 1,Angela Lombardi 1 andGaetano Santulli 1,2,4,*


l-Arginine is involved in many different biological processes and recent reports indicate that it could also play a crucial role in the coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Key Findings

Key Findings: The functional contribution of l-Arginine in many biological processes is extremely significant, especially in the control of endothelial and immune activities. There is a strong rationale indicating a beneficial effect of l-Arginine in COVID-19, and preliminary results from a randomized clinical trial seem to support this view.