Neuroprotective Effects of Proanthocyanidins, Natural Flavonoids Derived From Plants, on Rotenone-Induced Oxidative Stress and Apoptotic Cell Death in Human Neuroblastoma SH-SY5Y Cells

Year Published: 2018


Front Neurosci


Ma J, Gao SS, Yang HJ, Wang M, Cheng BF, Feng ZW, Wang L


Using a rat model to understand mechanisms, researchers investigated the effects of proanthocyanidin administration on outcomes associated with Parkinson's disease. Proanthocyanidins are flavonoid compounds that are found in peanuts.

Key Findings

Key Findings: Results showed that proanthocyanidins protected against cellular death and cell damage from reactive oxygen species. Authors concluded that proanthocyanidins may be effective in treating Parkinson's Disease.