p-Coumaric acid activates the GABA-A receptor in vitro and is orally anxiolytic in vivo

Year Published: 2014


Phytother Res


Scheepens A, Bisson JF, Skinner M


In this study, authors investigated the effect of p-coumaric acid on GABA. P-coumaric acid is a prominent antioxidant in peanuts. GABA is a neurotransmitter that regualted mood, stress, and anxiety

Key Findings

Key Findings: Results showed that p-coumaric acid was able to target the neurotransmitter GABA, and subsequently decrease anxiety and stress. Authors noted that p-coumaric acid had similar effects for reducing stress as one of the leading anxiety-reducing drugs, Diazepam.