Peanut lectin: Why it is not a peanut allergen

Year Published: 2024

Journal

Ann Allergy Asthma Immunol

Authors

Justin T Marsh 1 , Phil Johnson 1 , Joe Baumert 1 , Stef J Koppelman

Methods

Lectins are a class of protein, mainly found in plants, that specifically binds to carbohydrates. They have been used since the late 19th century for characterizing carbohydrate moieties on proteins, with blood group typing being an important example, and still have value today; for example, in studying sugar moieties on the severe acute respiratory syndrome coronavirus 2 virus. 1

Key Findings

Key Findings: Plant lectins, including peanut lectin, have been proposed for use in treating various human diseases, with antitumor, antiviral, antibacterial, and antifungal activities in addition to utility in drug targeting. 2 Peanut lectin has been purified and characterized by Lotan et al 3 as a 110 kDa tetramer of 4 identical monomers and has proved to be a valuable tool in glycobiochemistry.