Recent advances on the effect of nut consumption on cognitive improvement

Year Published: 2023


Food Frontiers


Weijie Wu, Ben Niu, Liang Peng, Qi Chen, Huizhi Chen, Hangjun Chen, Wei Xia, Long Jin, Jesus Simal-Gandara, Haiyan Gao


Cognitive disorders, including dementia, Parkinson’s and Alzheimer’s disease, pose significant public health issues. Preventing/delaying their onset is essential as effec- tive medical treatments are unavailable. Nuts contain bioactive compounds, including fatty acids, macronutrients such as proteins and dietary fibers, micronutrients, and polyphenols; these act synergistically preventing age-related diseases. Epidemiolog- ical investigations have established that high nut consumption reduces cognitive impairment risk, suggesting it is useful for cognitively impaired individuals; however, clinical data on the effects of nut consumption on cognitive function are lacking. This review summarized nut consumption effects on oxidative stress, inflammatory response, and gut microbiota.

Key Findings

Key Findings: Nuts reduce oxidative stress; their active substances, including glansreginin A, proanthocyanidins, quercetin, and nut oil, have signifi- cant anti-inflammatory effects. Furthermore, they comprise complex mixtures, which synergistically induce beneficial changes in the intestinal microbial community.