Single administration of resveratrol improves social behavior in adult mouse models of autism spectrum disorder

Year Published: 2020


Biosci Biotechnol Biochem


Shizu Hidema, Shohei Kikuchi, Ryoji Takata, Takaaki Yanai, Kenju Shimomura, Kengo Horie, Katsuhiko Nishimori


In this study, investigators induced autism in mice to test the effect of resveratrol (an antioxidant found in peanuts and grapes) on austism behavior. It is thought that deficiencies in the brain's oxytocin receptor is involved in autism development. So, the researchers looked at the effect of resveratrol on mice who lacked the oxytocin receptor.

Key Findings

Key Findings: After 24 hours of resveratrol injection, the social impairments caused by the lack of oxytocin receptor was improved. They also found that it activated the expression of several other genes involved in autism. Authors conclude that resveratrol may have a therapeutic effect on autism by affecting multiple targets.